Researchers have discovered for the first time, a genetic defect present in a type of microRNA in the fat cells of both women with PCOS and women with insulin resistance. The discovery paves the way for the development of new, targeted therapies to address the cause of both PCOS and insulin resistance. The research was published in the current issue of the journal Diabetes, and accompanied by a press release by the Medical College of Georgia, issued on Mar. 19, 2013.
A group of tiny RNA molecules with a big role in regulating gene expression also appear to have a role in causing insulin resistance in women with polycystic ovary syndrome and, perhaps, in all women, researchers report.
MicroRNAs (miRNA or uRNA) are single-stranded RNA molecules of 21-23 nucleotides in length, which regulate gene expression. miRNAs are encoded by genes from whose DNA they are transcribed but miRNAsarenot translated into protein.
Research in the journal Diabetes, indicates that high activity levels of a microRNA called miR-93 in fat cells impedes insulin’s use of glucose, contributing to PCOS as well as insulin resistance, said Dr. Ricardo Azziz, reproductive endocrinologist and PCOS expert at the Medical College of Georgia at Georgia Regents University