Lower levels of melatonin may be linked to significantly reduced sleep quality in women who have polycystic ovary syndrome (PCOS), a study reports. PCOS is an endocrine disorder that affects approximately 5-10 percent of women of childbearing age. It is a leading cause of infertility and occurs among all races and nationalities. It is the most common hormonal disorder among women of reproductive age.
Melatonin is a hormone that is made by the pineal gland. The synthesis and release of melatonin are stimulated by darkness and suppressed by light, suggesting that melatonin may be involved in circadian rhythm and the regulation of many body functions. Levels of melatonin in the blood are highest before bedtime.
Synthetic melatonin supplements have been used for a variety of medical conditions, most notably for disorders related to sleep. Previous studies suggest that women with PCOS may experience sleep problems.
In the current study, researchers looked at the link between sleep quality and levels of melatonin, as well as levels of a marker of oxidative stress called 8-hydroxydeoxyguanosine (8-OHdG). The team evaluated 26 women with PCOS and 26 control subjects, who completed sleep questionnaires for one month. Urine samples were collected at various time points, and the participants’ sleep patterns and lighting environment were monitored for three days and nights.
The results showed that women with PCOS had significantly high levels of melatonin and 8-OHdG in their urine at night, compared to controls. They also had significantly reduced sleep quality.
READ MORE AT SOURCE: http://naturalstandard.com/news/news201305005.asp
Previous studies haveidentifiedlinks between air pollution and other chronic conditions such as atherosclerosis and heart disease. However to date, epidemiological studies that have examined associations between long-term exposure to traffic-related air pollution and type 2 diabetesin adults are inconsistent, and studies on insulin resistance in children are scarce. Thus this new study sought to explore the possible association between air pollution and insulin resistance in children. “Although toxicity differs between air pollutants, they are all considered potent oxidisers that act either directly on lipids and proteins or indirectly through the activation of intracellular oxidant pathways,” says Heinrich. “Oxidative stress caused by exposure to air pollutants may therefore play a role in the development of insulin resistance. In addition, some studies have reported that short-term and long-term increases in particulate matter and nitrogen dioxide (NO2) exposure lead to elevated inflammatory biomarkers, another potential mechanism for insulin resistance.” In this new study, fasting blood samples were collected from 397 10-year-old children within a follow-up of two prospective German birth cohort studies. Individual-level exposures to traffic-related air pollutants at their birth address were estimated by analysing emission from road traffic in the neighbourhood, population density and land use in the area, and the association between air pollution and insulin resistance was calculated using a model adjusted for several possible confounders including socioeconomic status of the family, birthweight, pubertal status and BMI. Models were also further adjusted for second-hand smoke exposure at home. The researchers found that in all crude and adjusted models, levels of insulin resistance were greater in children with higher exposure to air pollution. Insulin resistance increased by 17% for every 10.6 µg/m3 (2 standard deviations [SDs] from the mean) increase in ambient nitrogen dioxide (NO2) and 19% for every 6 µg/m3 (2 SDs) increase in particulate matter of up to 10 μm in diameter. Proximity to the nearest major road increased insulin resistance by 7% per 500 metres. All the findings were statistically significant. Heinrich says: “There is some evidence that air pollution is associated with lower birthweight and growth restrictions —also shown previously in one of the cohortsof thepresent study — which are known risk factors for type 2 diabetes. Thus, one may speculate that lower birthweight is an intermediate step or ‘phenotype’ between air pollution and insulin resistance. However, we found no evidence to suggest that this may be true in our cohort of children, all of whom had birthweights above 2.5kg.”
READ MORE - SOURCE: http://www.sciencedaily.com/releases/2013/05/130509184817.htm
It may not have occurred to you but the grapefruit is hard to beat as a source of natural goodness in a healthy diet to better manage the symptoms of PCOS.
For a start, it has a low GI ratingof 25, which means it’s much less likely than an orange, for example, to causean exaggeratedinsulin response which triggers the hormonal imbalance that underlies PCOS. And if you are diabetic, it is less likely to causean artery-damagingspike inyourblood sugar.
Another plus with a grapefruit is its ability to help with weight loss because it’s high in fat-burning enzymes and low in sodium. Cutting salt in your diet can help flush out excess water caused byhigh sodium food.
Grapefruit also helps the proper digestion of food and boosts liver function, as well as providing a rich source of Vitamin C. Because it boasts a high concentration of lycopene, it may also help to prevent the onset of tumors.
Try and eat one grapefruit a day. Don’t cut it in half. Peel it like an orange for maximum benefit.
Christine DeZarn Polycystic Ovarian Syndrome Association,Inc. (PCOSA)
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PCOS can be difficult to diagnose and not all doctors are aware of PCOS, so it can be much more difficult than it should be. I would suggest looking into a new doctor, either an OB/GYN or GP. I am not aware if Endocrinologists have to be referred to by GP’s, but it wouldn’t hurt to look into, try to find one in or around your area because they specialize in hormones and the endocrine system. If you have symptoms and are not satisfied, make sure you keep pushing until you find that one doctor who won’t give up. There is a list of specific blood tests to get done that can help with diagnosing PCOS, which I will look for and post in this response, so please keep an eye on this message. I understand what you’re going through, though— it took a few years for a proper diagnosis and I wouldn’t stop until I found out the cause to the symptoms I was experiencing. Keep fighting and have hope! Don’t stop until you are satisfied with your diagnosis.
I would like to welcome all those who recently followed within the past two months. Last April, I created OurPCOS, and it was the best decision I made. I am so happy to connect and share experiences with those who have PCOS. When I was first diagnosed, I was devastated because PCOS was completely new to me, and like many of you, I had no one to turn to when in need of understanding.
There is plenty here — articles from PCOS websites, latest information, a range of recipes, fitness routines and videos, and plenty more. Now I am currently without a charger for my laptop so post from my phone, but I wanted to inform you all of the categories OurPCOS has to offer. Simply check out this link: http://ourpcos.tumblr.com/tagged/categories and you can explore! I will be updating as soon as I am at a working laptop.
I want to thank each and every one of you for making this past year wonderful. I have come to accept PCOS, realize it will always be a part of me, but I know it will never define who I am as a person, and I hope the same for all of you.